Lack of concordance in the effect of large doses of phenformin on insulin secretion and glycemia. Tentative analysis
Ribes, G.; Valette, G.; Lignon, F.; Loubatières-Mariani, M.M.
Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales 171(4): 870-875
1977
ISSN/ISBN: 0037-9026 PMID: 145295 Document Number: 111274
In the anesthetized dog normal or pretreated with phenformin (20 mg/kg per os) for 7 days, a subcutaneous injection of this biguanide (20 mg/kg) triggers a considerable hyperinsulinemia without concomitant hypoglycemia. The insulin secreted by these animals is biologically active on rat epididymal fat pads. On the other hand, epididymal fat pads of rats pretreated with phenformin display a lower response to insulin than that of non treated rats. The hypoglycemic effect of the same dose of insulin is less important in the normal dog after chronic pretreatment with phenformin.