Effect of two doses of pirenzepine on histamine-stimulated gastric acid secretion in man
Eugenides, N.; Stockbrügger, R.W.; Hobsley, M.; Cotton, P.B.
Scandinavian Journal of Gastroenterology. Suppl 72: 125-129
1982
ISSN/ISBN: 0085-5928 PMID: 6957980 Document Number: 183629
The effect of two dose-schedules of Pirenzepine (25 mg b.d. or 50 mg t.d.s. during 2 1/2 days) on histamine-stimulated gastric acid secretion was tested in eleven healthy volunteers. Gastric secretory responses were calculated as acid output values and as VG-values (VG = gastric secretory volume corrected for duodeno-gastric reflux and pyloric loss). Stimulated acid output per two hours was reduced with Pirenzepine 25 mg b.d. by 12.5% (n.s.), with Pirenzepine 50 mg t.d.s. by 21% (p less than 0.01). Stimulated VG per two hours was reduced with Pirenzepine 25 mg b.d. by 15.8% (p less than 0.01) and with Pirenzepine 50 mg t.d.s. by 24% (p less than 0.01). Pirenzepine reduces histamine-stimulated gastric acid output to a similar degree as other anticholinergic drugs. Reduction seems to be due to true inhibition of acid secretion and not to altered gastric motility.