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Effects of X-irradiation on the hybridization of rat thymus nuclear RNA with repeated and unique DNA sequences

Hanson, K.P.; Zhivotovsky, B.D.

International Journal of Radiation Biology and Related Studies in Physics Chemistry and Medicine 30(2): 129-139

1976

ISSN/ISBN: 0020-7616
PMID: 185163
Document Number: 109377
The kinetics of DNA hybridization with heterogeneous nuclear RNA (hnRNA) from normal and phytohaemagglutinin (PHA)-stimulated thymocytes has been studied in control rats and in animals 30 min after exposure to whole-body X-radiation with 400 rad. Irradiation results in a diminished ability of hnRNA to form hybrids with DNA at all C0t values ranging from 10(-3) to 10(4). Since this effect is most pronounced in the regions of low repetitive and unique DNA sequences, it is concluded that whole-body X-irradiation of animals may also suppress the transcription, particularly, in these regions.

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