Dopaminergic neurons: effects of electrical stimulation on tyrosine hydroxylase
Murrin, L.C.; Morgenroth, V.H.; Roth, R.H.
Molecular Pharmacology 12(6): 1070-1081
1976
ISSN/ISBN: 0026-895X PMID: 12461 Document Number: 109376
Electrical stimulation of the nigro-neostriatal and mesolimbic dopaminergic pathways was employed to examine the effects of increased impulse flow on the properties of tyrosine hydroxylase prepared from the AMP to high-speed supernatants prepared from the neostriatum produced kinetic changes in neostriatal tyrosine hydroxylase similar to those produced by increased impulse flow due to electrical stimulation. Addition of cAMP produced no further change in the properties of the enzyme already activated by electrical stimulation. Mechanisms by which impulse flow may control dopamine synthesis were discussed.