The role of adrenaline and ACTH in the process of complex heparin compound formation in the blood during imobilization stress
Kudriashov, B.A.; Shapiro, F.B.; Lomovskaia, E.G.; Liapina, L.A.
Problemy Endokrinologii 21(5): 54-59
1975
ISSN/ISBN: 0375-9660 PMID: 180515 Document Number: 95763
Intensification in immobilization stress of the process of formation of complex heparin compounds in the blood and a corresponding increase in the nonenzymatic fibrinolytic activity was largely determined by the altered hormonal status of theorganism: by adrenaline and ACTH discharge. In the animals with the ACTH secretion blocked by DOCA administration the nonenzymatic fibrinolytic activity in stress remained at the basal level characteristic of the nonstress situation. This activity remained at the basal level also after the block of the alpha-adrenoceptors by phentolaminehydrochloride. Administration of both adrenaline and ACTH considerably intensified in stress the process of formation of heparin complexes; no summation of the action of the exogenous ACTH and adrenaline occurred.