Role of dopamine receptors in the mechanism of formation of stress-induced stomach lesions
Groĭsman, S.D.; Karevina, T.G.; Khokholia, V.P.
Biulleten' Eksperimental'noi Biologii i Meditsiny 97(1): 57-60
1984
ISSN/ISBN: 0365-9615 PMID: 6229292 Document Number: 238280
Experiments on rats with the use of different exposures to stress (generalized electrization and "social stress") have demonstrated that stimulation of dopamine receptors localized in the central nervous system is one of the reasons for stress-induced gastric lesions, particularly for massive hemorrhages. Stimulation of peripheral dopamine receptors seems to have a gastroprotective action. As judged from the intensity of the effects of the dopamine agonists, apomorphine and L-DOPA, on stress-induced lesions of the gastric mucosa, stimulation of D2- rather than of D1-dopamine receptors is of greater importance in stress.