Influence of low doses of a heparin-urea complex on the aggregation of thrombocytes and the fibrinolytic activity of blood in intravenous infusion and in in vitro experiments
Kudriashov, B.A.; Patorova, V.E.; Liapina, L.A.
Farmakologiia i Toksikologiia 38(4): 441-444
1975
ISSN/ISBN: 0014-8318 PMID: 1213132 Document Number: 93247
An addition in in vitro experiments of a heparin-urea (HU) complex to a thrombocyte rich plasma completely blocked the onset of the thrombocytes aggregation, induced by thrombin, and reduced the degree of aggregation caused by adenosine-diphosphate. An intravenous administration of a 0.01% HU complex solution to rats 5 minutes after injection also blocked the thrombocytes aggregation induced by thrombin. The effect of the HU complex on the thromocytes aggregation proceeded against the background of a significantly delayed blood clotting time and an activation of of a fermentative and non-fermentative fibrinolysis, emerging after introduction of the heparin-urea complex.