Effects of various doses of SP 54 on fibrinolytic activity in patients with thrombotic diseases
Losonczy, H.; Nagy, I.; Dávid, M.
Folia Haematologica 115(3): 388-393
1988
ISSN/ISBN: 0323-4347 PMID: 2465236 Document Number: 321647
SP 54 was synthetized more than 30 years ago, but the proper oral dosage has not been established yet. Therefore we gave two doses. 150 and 500 mg to patients suffering from various arterial and venous thrombotic diseases, for investigating the dose-response effect. 16 patients received 150 mg, 14 patients 500 mg and 10 in each group both doses. We could observe significant changes in ELT, WBL and plasminogen level, but the increase of fibrinolytic activity was not dose-dependent in most cases. It indicates that an individual dosage is needed. Therefore we suggest an "SP 54 loading test" before prescribing the drug.