Effects of anti-inflammatory agents on plasma fibrinolytic activity
Bhargava, K.P.; Nath, R.; Tangri, K.K.
Indian Journal of Medical Research 64(7): 1094-1098
1976
ISSN/ISBN: 0019-5340 PMID: 992834 Document Number: 104466
The anti-inflammatory activity of a number of steroidal and non-steroidal anti-inflammatory agents was correlated against carrageenin-induced edema in albino rats with their plasma fibrinolytic activity. The order of anti-inflammatory potency of these agents was indomethacin > flufenamic acid > hydrocortisone > oxyphenbutazone > acetylsalicylic acid > amidopyrine > glycyrrhetic acid > phenacetin sodium salicylate. All these agents, except glycyrrhetic acid, prevented the increase in the plasma fibrinolytic activity associated with carrageenin-induced edema. No correlation could be made between the magnitudes of anti-inflammatory and anti-fibrinolytic activities of these agents.