Role of arterial wall in the process of local thrombus formation after endarterectomy
Zyrianov, B.N.; Nikitin, I.P.; Grib, N.D.
Vestnik Khirurgii Imeni I. I. Grekova 114(1): 63-67
1975
ISSN/ISBN: 0042-4625 PMID: 1226674 Document Number: 87305
The authors have studies the capacity of the endarterectomized arterial wall to release tissue factors of hemocoagulation in blood circulation. According to the investigations performed in 11 patients the endarterectomized artery releases into the circulation at least 3 substances showing a procoagulative action: thromboplastic factor, antiheparin substance and fibrinolysis inhibitors. The dynamics of these substances release into the circulation was studied by the authors experimentally on 74 dogs. The greatest disorders in the hemocoagulation potential at the site of endarterectomy were observed on the day of operation. The operated arterial wall would release the thromboplastic factor during 9 days, antiheparin substance during 5 days and fibrinolysis inhibitors up to 4 days following the operation. Arterial fragmentation is accompanied with reduction of the profibrinolysin content of tissue activator in the operated heart region. There was found a relationship between the process of regeneration of the endarterectomized arterial wall and dynamics of the release of tissue factors of hemocoagulation from it.