On a Series of Dicarbamates of 2,2-Disubstituted Propane-1,3-Dioles
Ferrari, G.; Casagrande, C.
Il Farmaco; Edizione Scientifica 18: 780-792
1963
ISSN/ISBN: 0430-0920 PMID: 14113065 Document Number: 9482
A series of ?-substituted propionaldehydes has been prepared from the corresponding mono-ethers of primary-tertiary glycols in the presence of an acid ion-exchange resin. The reaction is suitable for the synthesis of new compounds and also, in many ways, for the preparation of substances already known. The aldehydes have been subsequently transformed into the corresponding 2,2-disubstituted 1,3-propandiols and their dicarbamates using a known synthesis with important modifications. Mebutamate is among the compounds prepared. The principal characteristics and properties of the new compounds are described. In addition, some compounds have been subjected to pharmacological screening and appear to possess properties similar to those of meprobamate.
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