Visceral larva migrans: Immunoglobulins, precipitating antibodies and detection of IgG and IgM antibodies against Ascaris antigen
Patterson, R.; Huntley, C.C.; Roberts, M.; Irons, J.S.
American Journal of Tropical Medicine and Hygiene 24(3): 465-470
1975
ISSN/ISBN: 0002-9637 PMID: 1155690 Document Number: 88243
Serum samples from 10 children with visceral larva migrans were evaluated by analysis of immunoglobulin concentrations, precipitin reactions against Toxocara and Ascaris antigens and blood group substances, and IgM and IgG activity against Ascaris antigen by radioimmunoassay (RIA). The elevated concentrations of serum IgE and IgG and the positive precipitin reactions which occurred in some cases are an aid in diagnosis but were not consistently present. Serum IgM concentrations were elevated in all cases. IgM or IgG antibodies against A. suum antigen were detected in all cases by a solid phase RIA technique. RIA techniques of this type may provide a superior method of diagnosis, particularly if used with serial serum samples which demonstrate changing levels of antibodies. [AS].