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Role of VEGF-A gene in the formation of late effects after the Chornobyl accident

Ilyenko, I.M.

Problemy Radiatsiinoi Medytsyny Ta Radiobiolohii 18: 190-199

2013

ISSN/ISBN: 2304-8336
PMID: 25191724
Document Number: 670437
Meta. Oharakteryzuvaty osoblyvosti ekspresii' gena VEGF-A ta jogo osnovni efekty vidnosno klityn imunnoi' systemy uchasnykiv likvidacii' naslidkiv avarii' (ULNA) na ChAES. Materialy i metody. Provedeno ocinka zminy rivnja ekspresii' gena VEGF-A u lejkocytah peryferychnoi' krovi 55 osib metodom polimeraznoi' lancjugovoi' reakcii' u real'nomu chasi ta imunofenotypuvannja imunokompetentnyh klityn. Rezul'taty. Vstanovleni porushennja u reguljacii' neoangiogenezu u viddalenomu periodi pislja oprominennja. Vyznacheno pidvyshhenyj riven' ekspresii' gena VEGF-A, shho koreljuje z ekspresijeju gena TR53 u grupi ULNA na ChAES. Vstanovlenyj zvjazok mizh vidsotkom imunoreguljatornyh subpopuljacij T-klityn ta ekspresijeju VEGF-A v grupi oprominenyh osib ta prodemonstrovano prygnichennja specyfichnoi' imunnoi' vidpovidi CD4-8+ T-klityn. Vstanovleno koreljacijnu zalezhnist' mizh vidsotkom CD4+25+ klityn ta dozoju oprominennja u grupi ULNA na ChAES, jaka ne povjazana z ekspresijeju VEGF-A, shho daje pidstavy oharakteryzuvaty takyj typ imunologichnogo reaguvannja jak projav viddalenyh efektiv pislja oprominennja. Vysnovky. Vyznacheno rjad pokaznykiv, jaki harakteryzujut' stan ta porushennja u systemi „imunitet-angiogenez" ta mozhut' buty perspektyvnymy u prognozuvanni puhlynnogo procesu u viddalenomu periodi pislja oprominennja.

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