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Multiple myeloma among Chornobyl accident clean-up workers - state and perspectives of analytical study

Bazyka, D.A.; Gudzenko, N.A.; Dyagil, I.S.; Babkina, N.G.; Chumak, V.V.; Bakhanova, E.V.; Paramonov, V.V.; Romanenko, A.Y.

Problemy Radiatsiinoi Medytsyny Ta Radiobiolohii 18: 169-172

2013

ISSN/ISBN: 2304-8336
PMID: 25191721
Document Number: 669192
Meta: proanalizuvaty zahvorjuvanist' na mnozhynnu mijelomu (MM) sered uchasnykiv likvidacii' naslidkiv Chornobyl's'koi' katastrofy (ULNA) ta pidgotuvaty informacijnu osnovu dlja podal'shogo analitychnogo doslidzhennja dozozalezhnyh ryzykiv cijei' patologii', vrahovujuchy i'i' potencijnu radiacijnu zumovlenist'. Materialy i metody. Dlja identyfikacii' vypadkiv MM u doslidzhuvanij kogorti ULNA chysel'nistju 152 520 osib cholovichoi' stati buv provedenyj linkidzh bazy danyh kogorty z informacijnym masyvom Nacional'nogo kancerrejestru Ukrai'ny. Rezul'taty. Za doslidzhuvanyj period (1987–2012 rr.) bulo identyfikovano 64 vypadky, 58 z jakyh buly vkljucheni do poperedn'ogo analizu zahvorjuvanosti, vrahovujuchy 10-richnyj lag-period. Za rezul'tatamy poperedn'ogo analizu zahvorjuvanist' na MM u doslidzhuvanij kogorti ULNA ne perevyshhuvala harakternyj dlja zagal'nogo naselennja riven' protjagom pershyh 21 rokiv pislja avarii'. Vysnovok. Rozrahunok standartyzovanogo spivvidnoshennja zahvorjuvanosti (SIR) za period 2008–2012 rr., tobto cherez 22–26 rokiv pislja avarii', prodemonstruvav dostovirne perevyshhennja rivnja sered ULNA porivnjano zi spontannym populjacijnym rivnem dlja naselennja Ukrai'ny cholovichoi' stati (SIR 1.61, 95% CI 1.01;2.21). Pislja provedennja nezalezhnoi' diagnostychnoi' ekspertyzy vsih identyfikovanyh vypadkiv, rekonstrukcii' otrymanoi' dozy zovnishn'ogo oprominennja na chervonyj kistkovyj mozok za metodom RADRUE budut' proanalizovani dozozalezhni ryzyky vynyknennja MM z urahuvannjam mozhlyvogo modyfikujuchogo vplyvu inshyh faktoriv.

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