Top Abstract Purchase Related
Home
>
Node
>
Subnode

Allelic polymorphism of DNA repair gene XRCC1 in patients with thyroid cancer who were exposed to ionizing radiation as a result of the Chornobyl accident

Shkarupa, V.M.; Henyk-Berezovska, S.O.; Neumerzhytska, L.V.; Klymenko, S.V.

Problemy Radiatsiinoi Medytsyny Ta Radiobiolohii 19: 377-388

2014

ISSN/ISBN: 2304-8336
PMID: 25536575
Document Number: 677434
Metoju roboty bulo vyznachyty ta porivnjaty osoblyvosti polimorfizmu gena reparacii' XRCC1 Arg399Gln u hvoryh na rak shhytopodibnoi' zalozy (RShhZ), jaki zaznaly dii' ionizujuchoi' radiacii' vnaslidok avarii' na Chornobyl'skij AES, ta u hvoryh bez vplyvu ionizujuchogo vyprominennja v anamnezi. Materialy i metody. Vyznachennja polimorfizmu gena XRCC1 Arg399Gln provodylos' shljahom PLR u 102 hvoryh na RShhZ: 38 osib, jaki zaznaly dii' ionizujuchoi' radiacii' vnaslidok avarii' na Chornobyl'skij AES (ULNA, evakujovani ta meshkanci kontrol'ovanyh terytorij, zabrudnenyh radionuklidamy) ta 64 osoby bez vplyvu ionizujuchogo vyprominennja v anamnezi. Dlja porivnjannja otrymanyh danyh shhodo spontannogo ta radiacijno-asocijovanogo RShhZ ta rozrahunkiv vidminnostej chastot alelej i ryzyku vynyknennja onkopatologii' vykorystovuvaly dani literatury shhodo kontrol'nyh grup populjacij Rosijs'koi' Federacii' ta Bjelarusi. Rezul'taty. Chastota minornogo alelju gena XRCC1 Arg399Gln ta gomozygotnyh nosii'v c'ogo alelju u hvoryh na RShhZ, jaki zaznaly dii' ionizujuchoi' radiacii' vnaslidok avarii' na Chornobyl'skij AES dostovirno bil'sha, nizh u hvoryh bez vplyvu ionizujuchogo vyprominennja v anamnezi (0,57 i 0,37, r = 0,006 ta 34,21 i 7,81 % r = 0,001, vidpovidno). Pry porivnjanni z danymy literatury shhodo polimorfizmu XRCC1 Arg399Gln u radiacijno-eksponovanyh osib bez onkopatologii', ryzyk rozvytku RShhZ u gomozygotnyh nosii'v minornogo alelju XRCC1 Gln399Gln u osib, jaki zaznaly vplyvu ionizujuchogo vyprominennja, vyjavyvsja dostovirno pidvyshhenym: OR = 4,14, p = 0,001 (CI 95 % 1,72–9,93). Vysnovky. Nosijstvo gomozygotnyh minornyh alelej gena reparacii' DNK XRCC1 Gln399Gln je faktorom ryzyku rozvytku RShhZ za umov vplyvu IV v doslidzhenij grupi ukrai'ns'koi' populjacii'.

Document emailed within 1 workday
Secure & encrypted payments

Shkarupa, V.M.; Mishcheniuk, O.Y.; Henyk-Berezovska, S.O.; Palamarchuk, V.O.; Klymenko, S.V. 2016: Polymorphism of DNA repair gene XPD Lys751Gln and chromosome aberrations in lymphocytes of thyroid cancer patients exposed to ionizing radiation due to the Chornobyl accident Experimental Oncology 38(4): 257-260
Unizhakov, S.V.; L'vova, G.N.; Chekova, V.V.; Semiachkina, A.N.; Baleva, L.S.; Zasukhina, G.D.; Kazantseva, L.Z. 1995: Dna repair activity in children exposed to small doses of ionizing radiation as a result of the accident at the Chernobyl nuclear power station Genetika 31(10): 1433-1437
Bebeshko, V.G.; Bruslova, K.M.; Tsvietkova, N.M.; Volodina, T.T.; Kopylova, O.V.; Belingio, T.O.; Berezovski, S.A.; Petrunko, M.P.; Boyarskiy, V.G.; Polianska, V.M.; Pushkareva, T.I.; Mishchenko, L.P. 2014: Rationale treatment and preventive measures for correction of bone structure in children with acute leukemia, exposed to ionizing radiation due to the Chornobyl accident Problemy Radiatsiinoi Medytsyny Ta Radiobiolohii 19: 192-202
Kaminskyi, O.V.; Kopylova, O.V.; Afanasyev, D.E.; Pronin, O.V. 2015: Non cancer thyroid and other endocrine disease in children and adults exposed to ionizing radiation after the ChNPP accident Problemy Radiatsiinoi Medytsyny Ta Radiobiolohii 20: 341-355
Fuzik, M.M.; Prysyazhnyuk, A.Y.; Shibata, Y.; Romanenko, A.Y.; Fedorenko, Z.P.; Gudzenko, N.A.; Gulak, L.O.; Trotsyuk, N.K.; Goroh, Y.L.; Khukhrianska, O.M.; Sumkina, O.V.; Saenko, V.A.; Yamashita, S. 2013: Age and gender patterns of thyroid cancer incidence in Ukraine depending on thyroid radiation doses from radioactive iodine exposure after the Chornobyl NPP accident Problemy Radiatsiinoi Medytsyny Ta Radiobiolohii 18: 144-155
Chernyshov, V.P.; Vykhovanets', I.V.; Antypkin, I.H.; Klimenko, O.P. 2001: Interrelation between the peripheral blood lymphocyte phenotype and thyroid ultrasonic findings in children and adolescents exposed to the radiation as a result of the Chernobyl accident Likars'ka Sprava 1: 23-27
Kolpakov, I.I. 1999: Nonrespiratory lung functions in children who have undergone the chronic effect of ionizing radiation as a result of the accident at the Chernobyl Atomic Electric Power Station Likars'ka Sprava 5: 23-26
Stepanova, E.I.; Vdovenko, V.I. 2006: Health state and physical development of children prenatally exposed to radiation as a result of Chernobyl accident Likars'ka Sprava 4: 26-30
Ivanitskaia, N.F. 1992: Neuroendocrine disorders at long term in persons exposed to ionizing radiation after the accident at the Chernobyl Atomic Electric Power Station Likars'ka Sprava 1: 35-37
Mishcheniuk, O.Y.; Klymenko, S.V. 2013: Clinical risk factors of thrombosis in patients with Ph-negative myeloproliferative neoplasms, who had experienced radiation exposure due to the Chornobyl accident Problemy Radiatsiinoi Medytsyny Ta Radiobiolohii 18: 232-239
Kaminskyi, O.V.; Kopylova, O.V.; Afanasyev, D.Y.; Mazurenko, O.V.; Berezovskyi, S.Y. 2017: Pilot study of parathyroid glands in adult and pediatric subjects exposed to ionizing radiation after the ChNPP accident, methodology of parathyroid diagnostic ultrasound Problemy Radiatsiinoi Medytsyny Ta Radiobiolohii 22: 382-394
Minchenko, J.M.; Dyagil, I.S.; Dmytrenko, O.O.; Dmytrenko, I.V.; Shlaykhtychenko, T.Y.; Gavrylenko, T.I.; Biliy, D.O.; Khomenko, V.I.; Bebeshko, V.G. 2013: Role of radiosensitivity and radioresistance genetic markers in hematological and cardiovascular disease in persons exposed after the Chornobyl accident Problemy Radiatsiinoi Medytsyny Ta Radiobiolohii 18: 220-231
Ilyenko, I.M. 2013: Role of VEGF-A gene in the formation of late effects after the Chornobyl accident Problemy Radiatsiinoi Medytsyny Ta Radiobiolohii 18: 190-199
Tron'ko, N.D.; Boguslavskiĭ, V.P.; Prisiazhniuk, A.E.; Bol'shova, E.V. 1994: Incidence of thyroid cancer and its epidemiologic determinants: role of ionizing radiation Problemy Endokrinologii 40(3): 55-59
Manzoli, A.; Andreotti, F.; Varlotta, C.; Mollichelli, N.; Verde, M.; van de Greef, W.; Sperti, G.; Maseri, A. 1999: Allelic polymorphism of the interleukin-1 receptor antagonist gene in patients with acute or stable presentation of ischemic heart disease Cardiologia 44(9): 825-830
Loganovskiĭ, K.N. 1991: Psychopathological characteristics of autonomic dysfunction syndrome in patients exposed to small doses of ionizing radiation Vrachebnoe Delo 6: 68-72
Burlaka, A.P.; Druzhyna, M.O.; Vovk, A.V.; Lukin, S.М 2016: Disordered redox metabolism of brain cells in rats exposed to low doses of ionizing radiation or UHF electromagnetic radiation Experimental Oncology 38(4): 238-241
Tsyb, A.F.; Ivanov, V.K.; Aĭrapetov, S.A.; Gagin, E.A.; Maksiutov, M.A.; Rozhkov, O.V.; Stadnik, O.E.; Chekin, S.I.; Saakian, A.K. 1991: Radiation-epidemiologic analysis of the data of State Registry of persons exposed to radiation due to the Chernobyl AES accident Vestnik Akademii Meditsinskikh Nauk SSSR 11: 32-36
Dosenko, V.E.; Zagoriy, V.Y.; Haytovich, N.V.; Gordok, O.A.; Moibenko, A.A. 2006: Allelic polymorphism of endothelial NO-synthase gene and its functional manifestations Acta Biochimica Polonica 53(2): 299-302
Narita, M.; Narita, N.; Tazoe, M.; Sakuta, R.; Okado, N.; Nagai, T. 2001: A novel allelic variation of serotonin transporter gene polymorphism in anorexia nervosa No to Hattatsu 33(1): 74-75