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Comparative study of the effect of S-amlodipine nicotinate and amlodipine benzylate on the arterial pressure of awake rats

Gan'shina, T.S.; Kim, G.A.; Gnezdilova, A.V.; Gorbunov, A.A.; Mirzoian, R.S.

Eksperimental'naia i Klinicheskaia Farmakologiia 77(8): 20-22

2014

ISSN/ISBN: 0869-2092
PMID: 25335386
Document Number: 677433
We have performed a comparative study of the effects of two calcium channel blockers, S-amlodipine nicotinate and amnlodipine benzylate, on the arterial pressure (AP) of awake rats measured in the tail artery. The results of experiments showed that both preparations produce a statistically significant long-term decrease in the AP of animals. In respect of both strength and duration of the hypotensive effect, S-amlodipine nicotinate somewhat exceeds amnlodipine benzylate.

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