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Rationale treatment and preventive measures for correction of bone structure in children with acute leukemia, exposed to ionizing radiation due to the Chornobyl accident

Bebeshko, V.G.; Bruslova, K.M.; Tsvietkova, N.M.; Volodina, T.T.; Kopylova, O.V.; Belingio, T.O.; Berezovski, S.A.; Petrunko, M.P.; Boyarskiy, V.G.; Polianska, V.M.; Pushkareva, T.I.; Mishchenko, L.P.

Problemy Radiatsiinoi Medytsyny Ta Radiobiolohii 19: 192-202

2014

ISSN/ISBN: 2304-8336
PMID: 25536557
Document Number: 672052
Meta. Obg'runtuvaty ta ocinyty efektyvnist' likuval'no-profilaktychnyh zahodiv, zastosovanyh dlja korekcii' biohimichnyh i biofizychnyh zmin v strukturi kistkovoi' tkanyny u ditej, jaki zaznaly vplyvu ionizujuchogo oprominennja vnaslidok avarii' na ChAES, v dynamici lejkemichnogo procesu. Materialy i metody. Obstezheno 144 ditej, hvoryh na gostri limfota mijeloblastni lejkemii'. Doslidzhuvaly dozy oprominennja hvoryh, vmist kal'ciju, zagal'nogo bilku, luzhnoi' fosfatazy, kortyzolu i tyreotropnogo gormonu gipofizu v syrovatci krovi, kyslotno-luzhnu rivnovagu, ekskreciju fosfativ kal'ciju, sklad aminokyslot v sechi, shhil'nist' kistkovoi' tkanyny. Rezul'taty. U ditej z gostrymy lejkemijamy v I gostryj period ta pry provedenni himioterapii' vyjavleno znyzhennja pokaznyka densytometrii' kistok, rivnja kal'ciju, kortyzolu ta pidvyshhennja luzhnoi' fosfatazy v syrovatci krovi i oksyprolinu v sechi. V period remisii' zahvorjuvannja u bil'shosti hvoryh pokaznyky ne rozriznjalys' z grupoju porivnjannja. U 10,0 % ditej grupy porivnjannja vidmichajut'sja projavy osteopenichnogo syndromu. Dozy oprominennja hvoryh na gostri lejkemii' stanovyly 3,66 ± 0,11 mZv. Ne vstanovleno zv'jazku mizh dozamy oprominennja ta pokaznykamy, jaki harakteryzujut' stan struktury kistkovoi' tkanyny, i medianoju vyzhyvanosti hvoryh. Zastosuvannja kompleksu likuval'no-profilaktychnyh zahodiv u ditej, hvoryh na gostri lejkemii' v period remisii', spryjalo pozytyvnomu efektu u 62,0 %. Girshyj efekt sposterigavsja u pacijentiv z nespryjatlyvym perebigom zahvorjuvannja. Vysnovky. Rezul'taty doslidzhennja pokaznykiv metabolizmu kistkovoi' tkanyny svidchat' pro najavnist' zmin v organichnomu ta mineral'nomu matryksi jak u hvoryh na gostri lejkemii', jaki zaznajut' vplyvu ionizujuchogo oprominennja vnaslidok avarii' na ChAES, tak i osib bez onkogematologichnoi' patologii', ta neobhidnist' zastosuvannja likuval'no-profilaktychnyh zahodiv.

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