Disturbances of immune status and cytokine profile caused by chronic intoxication with organophosphorus compounds and their correction by administration of imunofan
Zabrodskiĭ, P.F.; Lim, V.G.; Strel'tsova, E.V.
Eksperimental'naia i Klinicheskaia Farmakologiia 75(2): 35-37
2012
ISSN/ISBN: 0869-2092 PMID: 22550858 Document Number: 658409
Experiments on noninbred rats showed that the chronic intoxication with organophosphorus compounds sarin and methylparathion (30 days; total dose, 0.9 LD50; single daily dose, 0.03 mg/kg,) significantly decreases the immune responses and reduces the concentrations of blood cytokines IFN-gamma, IL-2, IL-4, IL-6, and IL-10. The damage is more pronounced in Th1 cells than in Th2 lymphocytes. The administration of imunofan (single daily dose, 20 microg/kg) for 5 days partly recovers the immune status and the content of cytokines in the blood.