Assessment of the Cytokine Status in Employees in Conditions of Chronic Exposure to Vinyl Chloride
Bodienkova, G.M.; Alekseev, R.Y.
Gigiena i Sanitariia 94(5): 68-71
2015
ISSN/ISBN: 0016-9900 PMID: 26625621 Document Number: 680590
In the article there are presented the results of the evaluation of cytokine profile in males working in the production of vinyl chloride (trained workers without signs of disorders of the neuropsychic status and persons with early signs of neurointoxication with vinyl chloride, characterized by asthenic (emotional lability) disorder with the autonomic dysfunction). There are established differences of pro- and anti-inflammatory responses in workers in dependence on the severity of disorders of the neuropsychic status. The most pronounced imbalance of cytokines was in workers with initial manifestations of neurointoxication with vinyl chloride. The increase in the concentration of pro-inflammatory cytokines (IL-1β, IL-8, TNF-α) in trained employees without signs of disorders of the neuropsychic status is the one of the early and sensitive indices characterizing the formation ofthe body's resistance to exposure of adverse factors of production.