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The immune status and its correction in patients after reconstructive surgeries for cicatricial stenosis of trachea

Larina, T.V.; Bondarenko, A.V.; Bogomolova, N.S.; Vinnitskĭ, L.I.; Buniatian, A.A.; Nikoda, V.V.

Anesteziologiia i Reanimatologiia 2004(5): 83-85

2004

ISSN/ISBN: 0201-7563
PMID: 15573735
Document Number: 569879
The immune status was analyzed in 28 patients with cicatricial stenosis of the trachea for the purpose of determining the type and nature of affection as well as for the purpose of evaluating the clinical efficiency of galavit immunomodulator. Combined impairments were diagnosed in the patients. Moderately decreased CD4+, CD8+, CD16+, significantly decreased CD25+, HLA-DR, CD71+ and increased CD4+/CD8+ were detected at the cell level. An essentially lower CD20+, a higher content of IgG and a reduced FAN were observed in the humoral chain. Therefore, galavit, when used preoperative and immediately after surgery in patients with cicatricial stenosis of the trachea, had a positive effect on the immune status; it reliably increased the count of T-helpers (CD4+) and of natural killers (CD16+) and it induced the phagocyte activity of neutrophils.

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