Effect of cholinesterase reactivator carboxim on T-lymphocyte acetylcholinesterase activity and immune response under conditions of acute intoxication by organophosphorus compounds
Zabrodskiĭ, P.F.; Strel'tsova, E.V.; Grishin, V.A.
Eksperimental'naia i Klinicheskaia Farmakologiia 74(10): 31-33
2011
ISSN/ISBN: 0869-2092 PMID: 22238984 Document Number: 652277
It has been established in experiments on non-inbred rats that the administration of cholinesterase reactivator carboxim in a single dose of 10 mg/kg signifucantly reduces the inactivation of acetylcholinesterase in T-lymphocytes caused by acute intoxication with organophosphorus compounds (sarin, metaphos) in a dose of 1.0 LD50. The drug administration leads to partial or almost complete recovery of the humoral and cellular immune responses. Carboxim does not influence the T-independent humoral immune response reduced due to suppression of B-cell (plasmocyte) function by organophosphorus compounds.