Immune response gene control of determinant selection. II. Genetic control of the murine T lymphocyte proliferative response to insulin
Rosenwasser, L.J.; Barcinski, M.A.; Schwartz, R.H.; Rosenthal, A.S.
Journal of Immunology 123(1): 471-476
1979
ISSN/ISBN: 0022-1767 PMID: 87482 Document Number: 143679
It was found, for 2 responder strains of mice, that each recognises a different determinant on the insulin molecule. H-2b mice recognise a determinant in the A-chain loop of insulin whereas H-2d mice recognise a determinant that resides in the B-chain, possibly in the last 8 amino acids. Using H-2 recombinant strains of mice, the location of the Ir gene control of the response to both determinants was mapped to the K region and/or IA subregion of H-2. The possibility of non-MHC regulation of MHC-controlled immune responses is suggested by studies of recombinant inbred strains of mice.