Adherent cell function in murine T lymphocyte antigen recognition. III. A macrophage-mediated immune response gene function in the mouse
Rosenwasser, L.J.; Rosenthal, A.S.
Journal of Immunology 123(3): 1141-1144
1979
ISSN/ISBN: 0022-1767 PMID: 89161 Document Number: 151463
The I region of the MHC appears to control antigen-specific macrophage/T-cell interaction. The immune response to antigens such as Gloe (L-Glu,L-Lys,L-Phe) is under control of 2 distinct I subregions, IA and IE/IC. In a macrophage-dependent, antigen-specific, murine T-cell proliferation assay to determine whether either or both gene products need be expressed in the antigen-presenting cells, it was found that both Ir-Gloe alpha and beta genes must be expressed and function in the antigen-presenting cell. [For Pt. II see ABA 47, 3860].