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Effect of benzonal on the resistance of animals to the action of organophosphorus and carbamic compounds

Kagan, I.S.; Kokshareva, N.V.; Savateev, N.V.; Liniuchev, M.N.; Sergeev, V.V.

Farmakologiia i Toksikologiia 46(5): 100-103

1983

ISSN/ISBN: 0014-8318
PMID: 6628651
Document Number: 216799
The inductor of microsomal enzymes, benzonal (20 mg/kg) produces an overt preventive and treatment-preventive action in acute and subacute poisoning with organophosphorus (DDVP, parathion, TEPP, chlorophos) and carbamic (pirimor, sevin) compounds. As regards the efficacy benzonal is not inferior to phenobarbital (14 mg/kg). Pretreatment with benzonal averts the development of the neuromuscular blockade and normalizes spontaneous activity of the myoneural synapse of rats and cats poisoned with pirimor and parathion.

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