Screening and characteristics of regulators of landomycin e biosynthesis in Streptomyces globisporus
Matseliukh, B.P.; Tymoshenko, S.H.; Bambura, O.I.; Kopeĭko, O.P.
Mikrobiolohichnyi Zhurnal 73(5): 16-20
2011
ISSN/ISBN: 0201-8462 PMID: 22164695 Document Number: 650954
The screening of the positive regulators of landomycin E biosynthesis has been conducted among exogenous metabolites of the museum and freshly isolated Streptomycetes strains by means of cosynthesis test using mutant strain Streptomyces globisporus 1912-82. The ability to produce the exogenous metabolites restoring landomycin E biosynthesis by B2 strain was shown. The regulatory compounds purified by thin-layer chromatography differed between themselves by chromatographic mobility (Rf) and maxima of absorption in UV-light. They were divided into four types of extracellular regulators of landomycin E biosynthesis on the basis of preliminary study.