Biosynthesis of the antibiotic, grizin, by prototrophic revertants of Streptomyces griseus biochemical mutants
Kuklin, V.V.; Iustratova, L.S.; Zhdanov, V.G.
Antibiotiki 25(6): 403-407
1980
ISSN/ISBN: 0003-5637 PMID: 6249189 Document Number: 168372
Spontaneous and nitrosomethylbiuret-induced prototrophic revertants of various biochemical mutants of Str. griseus producing grisin, a streptothricin antibiotic, were isolated. The antibiotic production level of the revertants was studied. It was found that most of the prototrophic revertants synthesized much higher amounts of grisin than the initial biochemical mutants. It was also shown that a number of the prototrophic revertants of the methionine- and arginine-dependent mutants synthesized 20-23% higher amounts of grisin as compared to the control.