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Anthracycline antibiotic 2-hydroxyaclacinomycins. I. 2-Hydroxyaclacinomycin-producing recombinant obtained from aclacinomycin-blocked mutants of Streptomyces galilaeus by a technique of protoplast fusion

Yoshimoto, A.; Johdo, O.; Ishikura, T.; Takeuchi, T.

Japanese Journal of Antibiotics 44(3): 269-276

1991

ISSN/ISBN: 0368-2781
PMID: 1880909
Document Number: 382550
The technique of protoplast fusion which optimized prototrophic recombination in aclacinomycin-producing Streptomyces galilaeus was studied and applied to the contruction of new anthracycline analog-producing recombinant upon genetic cross of two specific mutants blocked in aclacinomycin biosynthesis. Thus, 2-hydroxyaclacinomycin-producing recombinant was obtained by the protoplast fusion.

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