Actinomyces streptomycini mutants blocked in the biosynthesis of the streptobiosamine portion of the streptomycin molecule
Krasil'nikov, O.L.; Anisova, L.N.; Khokhlov, A.S.
Antibiotiki 23(2): 135-138
1978
ISSN/ISBN: 0003-5637 PMID: 629525 Document Number: 135269
Four low active mutants of Act. streptomycini were obtained under the effect of nitrozo-methylbiuret. The mutants increased their antibiotic production level, when streptobiosamine was present in the formentation medium. It was shown that in 3 out of the 4 mutants the highest antibiotic yield was in the medium containing streptobiosamine in an amount of 1 mg/ml and in 1 strain the highest yield was in the medium with 0.5 mg/ml of streptobiosamine. When the mutants were grown in a medium containing N-methyl-L-glucosamine no increase in streptomycin production was registered.