Top Abstract Purchase Related
Home
>
Node
>
Subnode

Separation of the biosynthesis products of a mutant strain of Actinomyces chrysomallus var. carotenoides and the identification of actinomycin antibiotics

Sverdlova, A.N.; Nefelova, M.V.; Silaev, A.B.

Antibiotiki 24(1): 7-11

1979

ISSN/ISBN: 0003-5637
PMID: 85432
Document Number: 142042
An orange antibiotically active substance isolated from the mycelium of a mutant strain of Actinomyces chrysomallus var. carotenoides was identified as a mixture of actinomycins according to its light absorption spectra, circular dichroism spectra, IR spectra and chromatographic comparison with the standard samples. A scheme for successive extraction of the biologically active substances from the mycelium resulting in isolation of a fraction enriched with antibiotic substances and a fraction enriched with pigments is presented. A method for separation and purification of 3 groups of biologically active substances from the mycelium enriched extract was developed.

Document emailed within 1 workday
Secure & encrypted payments

Sverdlova, A.N.; Silaev, A.B.; Alekseeva, L.N.; Nefelova, M.V. 1977: Participation of acetate in the biosynthesis of carotenoids and macrotetralids by Actinomyces chrysomallus var. carotenoides Mikrobiologiia 46(6): 1122-1123
Kuznetsova, V.S.; Orlova, T.I.; Silaev, A.B. 1973: Metabolites of an actinomycin nature from Actinomyces sp. strain No. 2 Antibiotiki 18(6): 497-500
Anisova, L.N.; Kovalenko, I.V.; Kornitskaia, E.I.; Krasil'nikova, O.L.; Soĭfer, V.S. 1976: Actinomyces streptomycini mutant blocked in streptidine biosynthesis Antibiotiki 21(1): 6-10
Ostrikova, N.A.; Konovalov, S.A. 1983: Effect of nitrogen sources on cellulase biosynthesis by a mutant strain of Trichoderma viride 44 Prikladnaia Biokhimiia i Mikrobiologiia 19(4): 498-502
González-Cadavid, N.F.; Pérez, J.L. 1976: Identification of the products of mitochondrial transcription in the walker corcinosarcoma by the use of actinomycin D and ethidium bromide Cancer Research 36(5): 1754-1760
Bryzgalova, T.E.; Orlova, N.V. 1976: Study of the chemical makeup of the mycelium from an active strain of Act. rimosus and from an inactive mutant in relaiton to oxytetracycline biosynthesis Antibiotiki 21(1): 14-19
Kuimova, T.F.; Titova, E.F.; Belavtseva, E.M.; Artamonova, O.I. 1978: Electron microscopic study of the surface of Actinomyces chrysomallus spores by the freeze etching method Mikrobiologiia 47(3): 545-548
Ben Yaghlane-Bouslama, H.; Petit, A.; Sofer, L.; Sirot, J.; Boujnah, A.; Kallel, H.; Labia, R. 1992: Identification of a new penicillinase in a Klebsiella pneumoniae strain of which a mutant also produces an esterase hydrolyzing cephalothin and cefotaxime Pathologie-Biologie 40(1): 31-35
Jacobs, F.J.; Fischer, R.; Wighman, A. 1971: Thin layer chromatographic separation and identification of some hydrolysis products of mucopolysaccharides Pharmaceutisch Weekblad 106(11): 93-102
Thielemann, H. 1978: Contribution to paper chromatography separation and identification of reaction products in a system of aqueous polyphenol solutions and chloridioxide Zeitschrift für die Gesamte Hygiene und ihre Grenzgebiete 24(11): 889-890
Kuznetsova, V.S.; Orlova, T.I.; Silaev, A.B. 1972: Minor actinomycins from Actinomyces species No. 2--producer of the actinomycin antibiotic aurantin Antibiotiki 17(4): 322-325
Sverdlova, A.N.; Agbenoko, K.; Egorov, N.S. 1995: Antibiotics, synthesized by Streptomyces chrysomallus subsp. macrotetrolidi in the early stages of growth Antibiotiki i Khimioterapiia 40(11-12): 3-9
Kremen, J.; Stríbrná, J.; Sula, J. 1978: Effect of actinomycin D and daunomycin on the biosynthesis of nucleic acids in cells transformed by oncornavirus and on the biosynthesis of viral nucleic acids Sbornik Lekarsky 80(5): 136-141
Levitov, M.M.; Navol'neva, I.N.; Meshkov, A.N. 1974: Effect of the nature of the nitrogen nutrition on protease biosynthesis by Actinomyces 771 Mikrobiologiia 43(1): 76-82
Laznikova, T.N.; Makarevich, V.G. 1971: Effect of amino acids on the growth of Actinomyces aureofaciens and biosynthesis of tetracycline Antibiotiki 16(3): 207-212
Takahashi, M.; Ichiman, Y.; Ohtomo, T.; Usui, Y.; Ohshima, Y. 1985: Studies on sub-MIC activities of beta-lactam antibiotics and aminoglycoside antibiotics against clinically isolated strain Japanese Journal of Antibiotics 38(12): 3497-3504
Krasil'nikov, O.L.; Anisova, L.N.; Khokhlov, A.S. 1978: Actinomyces streptomycini mutants blocked in the biosynthesis of the streptobiosamine portion of the streptomycin molecule Antibiotiki 23(2): 135-138
Vybornykh, S.N.; Arkadyeva, Z.A.; Egorov, N.S. 1975: Storage of the thermophilous Actinomyces thermovulgaris strain T-54--producer of proteolytic enzymes Prikladnaia Biokhimiia i Mikrobiologiia 11(3): 374-377
Fedorenko, V.A. 1999: Genetic mechanisms of Actinomyces resistance to aminoglycoside antibiotics Antibiotiki i Khimioterapiia 44(9): 29-36
el-Naggar, M.Y.; el-Kersh, M.A.; el-Sharaky, A.S. 1999: Correlation of actinomycin X2 to the lipid profile in static and shaken cultures of Streptomyces nasri strain YG62 Microbios 100(396): 117-127