Use of a protoplasting method for altering the qualitative and quantitative composition of the anthracycline complex in Streptomyces peucetius var. caesius
Krasil'nikova, O.L.; Anisova, L.N.; Romanova, N.B.; Bartoshevich, I.E.
Antibiotiki i Khimioterapiia 33(7): 483-486
1988
ISSN/ISBN: 0235-2990 PMID: 3056300 Document Number: 314883
Conditions for efficient regeneration in mutant strains of the doxorubicin-producing organism Str. peucetius var. caesius were developed. The effect of the protoplast regeneration on changes in the proportion of the components of the anthracycline complex produced by these strains was shown. Variants with doxorubicin productivity 2 times higher than that of the parent strain were isolated.
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