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Effect of protoplasting on antibiotic activity and resistance in the strain Streptomyces hygroscopicus 155

Ivanova, I.V.; Khristova, K.G.; Tishkov, S.K.; Moncheva, P.A.

Antibiotiki i Khimioterapiia 37(11): 3-5

1992

ISSN/ISBN: 0235-2990
PMID: 1300932
Document Number: 401467
The influence of protoplasting and protoplast regeneration in the presence of polyethylene glycol on antibiotic activity, components of antibiotic complexes and antibiotic resistance in Streptomyces hygroscopicus 155 was studied. It was shown that the protoplasting and protoplast regeneration influenced the antibiotic activity. The protoplast fusion resulted in increased isolation of variants with higher antibiotic activity. The processes also affected the components of the antibiotic complexes but had no effect on the strain resistance to some antibiotics.

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