Some characteristics of fucidin biosynthesis
Penzikova, G.A.; Stepanova, N.E.; Levitov, M.M.
Antibiotiki 20(10): 867-871
1975
ISSN/ISBN: 0003-5637 PMID: 1211884 Document Number: 84557
Some features of fusidin biosynthesis by 2 strains of Fusidium coccineum were studied proceeding from the peculiar properties of the antibiotic molecule structure. It was found that an increase in the levels of the carbon sources in the medium stimulated the biosynthesis of fusidin, while excessive concentrations of nitrogen especially in its inorganic and amino acidpeptide forms stimulated the organism growth and lowered the antibiotic activity levels. The concentration of nitrogen in the medium is considered as one of the possible control mechanisms in the processes of the fungus growth and biosynthesis of fusidin.