Mutagen properties of water-soluble polysaccharides from Acorus calamus
Gur'ev, A.M.; Belousov, M.B.; Akhmedzhanov, R.R.; Iusubov, M.S.; Voronova, O.L.; Karpova, G.V.; Churin, A.A.
Eksperimental'naia i Klinicheskaia Farmakologiia 73(8): 43-45
2010
ISSN/ISBN: 0869-2092 PMID: 20919559 Document Number: 645128
Mutagenic properties of water soluble polysaccharides (WSPS) extracted from Acorus calamus L. have been studied. Neither a single intravenous injection nor a course intraperitoneal introduction of WSPS in a dose of 1/2 LD50 to mice of the CBA/CaLac line increases the level of cytogenetic disorders in the bone marrow cells. The investigation of WSPS by means of the somatic mosaicism test showed that the given dose of WSPS does not increase the rate of mutant spots on Drosophila wings.