Synthesis and anti-active oxygen properties of water-soluble metal porphyrins
Feng, Q.; Liu, L.; Luo, F.; Sun, D-na.; Li, Z-ying.; Zhang, Y-ning.
Yao Xue Xue Bao 39(9): 711-715
2004
ISSN/ISBN: 0513-4870 PMID: 15606019 Document Number: 584114
Aim To synthesize four water-soluble metal porphyrins (5, 10, 15, 20-tetra (4-( 4'-pyridine-1) butyloxy phenyl) metalloporphyrins bromide, metal = Zn (I), Cu (II), Mn (III) and Co (IV)) as analogous enzyme having two anti-active oxygen functions. Methods The first function, scavenging O2-, has been proved by using riboflavine-methionine photoreduction methods. The second function, scavenging H2O2, has been demonstrated by using the oxidating Vit C. The third function, scavenging HO., has been demonstrated by using Fenton reaction. The complexes were measured by the mice liver homogenate technique of mice. Results Four model compounds could scavenge O2- in the concentration range of 1.0 x 10-5 - 1.0 x 10-6 mol . L-1, decompose H2O2 in the concentration of 1.5 x 10-6 - 1.0 x 10-6 mol . L-1, scavenge HO. in the concentration of 2.0 x 10-8 - 1.0 x 10-8 mol . L-1. All showed that they had obvious action of decreasing the lipid peroxidation in the concentration of 1.0 x 10-7 mol . L-1. Conclusion All above-mentioned complexes were considered to be qualified analogous enzymes of anti-active oxygen.