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New biologically active theophylline derivatives. Synthesis and pharmacologic properties of flufylline and fluprofylline

Thiele, K.; Jahn, U.; Geissmann, F.; Zirngibl, L.

Arzneimittel-Forschung 34(1): 1-4

1984

ISSN/ISBN: 0004-4172
PMID: 6608355
Document Number: 241926
Within the course of the research project for finding new cardiovascular drugs we have synthetized since 1976 piperazine- and piperidine derivatives of theophylline. The screening shows for the substances Sgd 19578 (flufylline) and Sgd 14480 (fluprofylline) a long-lasting blood pressure lowering activity as well as a remarkable serotonin- and histamine antagonism and broncholytic activity. On the basis of these results these compounds were selected for further investigation.

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