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Analysis of functional properties of biologically active substances using eukaryotic cell models (review)

Lisitskaia, K.V.; Nikolaev, I.V.; Torkova, A.A.; Popov, V.O.; Koroleva, O.V.

Prikladnaia Biokhimiia i Mikrobiologiia 48(6): 581-599

2012

ISSN/ISBN: 0555-1099
PMID: 23330384
Document Number: 656335
This work presents an analysis of current data on the investigation into the functional properties of biologically active substances in model systems based on cultivated human cells. The knowledge regarding the practical application of cell cultures for the analysis of functional properties of bioactive substances is summarized, including antioxidant, immunomodulating, pro- and prebiotics, and chemoprevention properties. The most promising directions in cell culture model development for the investigation of functional properties, including three-dimensional models, are discussed.

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