Stability of parenteral solutions of sodium cephalothin, cephaloridine, potassium penicillin G (buffered) and vancomycin hydrochloride
Mann, J.M.; Coleman, D.L.; Boylan, J.C.
American Journal of Hospital Pharmacy 28(10): 760-763
1971
ISSN/ISBN: 0002-9289 PMID: 5125170 Document Number: 5783
The clinical convenience of preparing in advance antibiotic solutions for intravenous administration has necessitated the availability of solution stability data. Refrigerated and room temperature solution stability profiles for sodium cephalothin, cephaloridine, potassium penicillin G (buffered) and vancomycin hydrochloride in 5% dextrose, 0.9% saline and water for injection are reported. The need to obtain precise data by methods such as those described in the Code of Federal Regulations is discussed. The necessity of evaluating activities of antibiotics in solution in terms of biologically active degradation products, integrity of parent compound, pH and physical characteristics is also discussed.
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