Stability of parenteral solutions of tobramycin sulfate
Bergstrom, R.F.; Fites, A.L.; Lamb, J.W.
American Journal of Hospital Pharmacy 32(9): 887-888
1975
ISSN/ISBN: 0002-9289 PMID: 242216 Document Number: 90561
The stability and physical compatibility of tobramycin sulfate in commonly used intravenous fluids were evaluated; in addition, pH values were obtained on 1 mg/ml tobramycin solutions, and microbiological potencies were obtained on 1 mg/ml and 0.2 mg/ml concentrations for 24- and 48-hour periods at 25 C. Most solutions were stable for 48 hours at room temperature. However, it is recommended that solutions of tobramycin sulfate be discarded after 24 hours to minimize the potential for inadvertent introduction of microorganisms during manipulations in the hospital environment.