New analogue of cyclolinopeptide B modified by amphiphilic residue of alpha-hydroxymethylmethionine
Witkowska, R.; Donigiewicz, A.; Zimecki, Mł.; Zabrocki, J.
Acta Biochimica Polonica 51(1): 67-72
2004
ISSN/ISBN: 0001-527X PMID: 15094826 Document Number: 572607
In order to evaluate the role and influence of the methionine residue on the biological activity of cyclolinopeptide B, an analogue with methionine residue in position 7 replaced by the amphiphilic (S)-alpha-hydroxymethylmethionine residue was synthesized. This peptide exhibits high immunosuppressive activity in the cellular, and to a lesser degree in the humoral immune response, comparable to that of CsA. In addition, the peptide was devoid of toxicity, even at high doses.
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