Management of severe postpartum hemorrhage due to uterine atony using an analogue of prostaglandin F2 alpha
Hayashi, R.H.; Castillo, M.S.; Noah, M.L.
Obstetrics and Gynecology 58(4): 426-429
1981
ISSN/ISBN: 0029-7844 PMID: 6974335 Document Number: 581652
Patients (20) with severe postpartum hemorrhage due to uterine atony who were unresponsive to conventional therapy were treated with 0.25-mg i.m. injections of (15-S)-15-methyl prostaglandin F2.alpha.-tromethamine. A rapid and successful response was obtained in 18 patients. Two patients required surgical procedures to control bleeding. Both patients with treatment failure had chorioamnionitis. Side effects of the prostaglandin therapy included nausea, vomiting and diarrhea, a transient mild temperature elevation and a transient moderate blood pressure elevation. Those subjects with preeclampsia did not demonstrate a serious elevation of blood pressure. The prostaglandin F2.alpha. analog appears to be very effective in the treatment of postpartum hemorrhage due to uterine atony.