Quantitative structure-activity studies on hallucinogenic mescaline analogs using modified first order valence connectivity
Gupta, S.P.; Bindal, M.C.; Singh, P.
Arzneimittel-Forschung 32(10): 1223-1225
1982
ISSN/ISBN: 0004-4172 PMID: 6891219 Document Number: 5690
Attempt is made to correlate the hallucinogenic activity of a series of mescaline analogs with Kier's molecular connectivity index (chi). In order to find a simpler and more meaningful correlation, a little modification is suggested to the first-order valence connectivity index (1 chi upsilon). The modification is found to reveal utterly simple but significant correlations between activity and 1 chi upsilon, which could describe the structural influence on the activity more vividly.
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