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Function analysis of regulative region of transforming gene Tx related to human nasopharyngeal carcinoma

Peng, B.; Zhou, M.; Cao, L.; Li, G.; Yao, K.

Hunan Yi Ke da Xue Xue Bao 23(4): 335-338

1998

ISSN/ISBN: 1000-5625
PMID: 11189386
Document Number: 495989
Tx gene is the DNA sequence with transforming activity which was cloned from the epithelial cell line (CNE2) of human nasopharyngeal carcinoma (NPC). In order to understand the role of Tx in carcinogenesis of NPC, the promoter function of potential promoter region in Tx2. 8 was detected using CAT reporter assay. The results showed that the region has no promoter function. It suggested that Tx2. 8 kb fragment homogenous to IGKC might be regulated by the specific mechanism of immunoglobulin gene.

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