Serological analysis of human leukocyte antigens-A and -B antigens in Thai patients with nasopharyngeal carcinoma
Pimtanothai, N.; Kangwanshiratada, O.; Charoenwongse, P.
Journal of the Medical Association of Thailand 86(Suppl): S237-S241
2003
ISSN/ISBN: 0125-2208 PMID: 12929995 Document Number: 2510
Objective: To study the distribution of human leukocyte antigens (HLA)-A and -B antigens by standard microlymphocytotoxicity assay in Thai nasopharyngeal carcinoma (NPC) patients compared to normal controls in order to identify the alleles associated with NPC in Thailand. Design: Retrospective-Analytical study. Subjects: Fifty-three unrelated Thai patients with histologically confirmed NPC diagnosed at King Chulalongkorn Memorial Hospital and 70 healthy unrelated Thai individuals served as controls. Method: Lymphocyte separation and HLA typing were performed from freshly drawn blood by standard microlymphocytotoxicity assay. The significance of differences between the two groups was analyzed by the chi-square test. Results: HLA-A2 was observed at a greater frequency in patients being found in 31/53 (58%) NPC patients compared to 27/70 (38%) controls (p=0.02). An increase in HLA-B46 was also demonstrated. HLA-B46 was present in 16/53 (30%) NPC patients but was observed in 10/70 (14%) in controls (p=0.03). Conclusions: This study reported two susceptible, HLA-A2 and HLA-B46 antigens, for NPC in a Thai population.