Human leukocyte antigens and sister chromatid exchanges in families with multiple adenomatosis coli
Illeni, M.T.; Agazzi, C.; Doci, R.; Lombardo, C.; Mascheretti, E.; Audisio, R.A.
Cancer Detection and Prevention 9(5-6): 459-468
1986
ISSN/ISBN: 0361-090X PMID: 3022927 Document Number: 271646
To study human leukocyte antigens (HLA) and sister chromatid exchanges (SCE) in multiple adenomatosis coli (MAC), eight families were evaluated. Twenty-five subjects (14 affected members and 11 healthy relatives) were studied with HLA A, B, and C typing of peripheral lymphocytes and SCE count in cells that had replicated twice. The results of the present immunogenetic study, although limited to a small number of cases, suggest a correlation between HLA, SCE, and MAC. When the results of further investigations on larger series confirmed by clinical follow-up of these subjects are available, these methods might give useful information in predicting the risk of each family member to become affected by MAC and consequently develop a colorectal carcinoma.