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Frequency and distribution of sister chromatid exchanges in human peripheral lymphocytes

Alhadeff, B.; Cohen, M.M.

Israel Journal of Medical Sciences 12(12): 1440-1447

1976

ISSN/ISBN: 0021-2180
PMID: 1017942
Document Number: 104735
The frequency and distribution of sister chromatid exchanges (SCE) were examined in a population of 10 normal individuals (five males and five females) and compared with those in patients with various numerical and structural chromosomal aberrations. Statistically significant differences within each group were observed among the normal subjects as well as among patients with similar cytogenetic aberrations. A consistent nonrandom distribution of SCE, with regard to chromosome length, was demonstrated, with a significant increase of SCE in the centromere region of some chromosomes.

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