Sister chromatid exchanges induced by sarcolysine in human lymphocytes in vitro
Moraru, I.; Georgian, L.; Roman, I.C.; Drăghicescu, T.
Morphologie et Embryologie 31(1): 5-7
1985
ISSN/ISBN: 0377-5038 PMID: 3157053 Document Number: 258782
The effect of three concentrations of sarcolysine (0.5 micrograms/ml, 1 microgram/ml and 2 micrograms/ml) on the sister chromatid exchanges (SCE) was investigated in human lymphocytes in vitro. A dose related increase in SCEs frequencies was observed after sarcolysine administration and also a delayed development of cell cycle has been induced by the two last concentrations. The variation range of SCEs per cell was dose-dependent and it was considered to represent the acquired genetic instability induced by the drug.