Radiation-induced chromosome aberrations and sister chromatid exchanges in lymphocytes from patients with tuberous sclerosis
IIjima, S.; Higurashi, M.; Takeshita, T.; Kawasaki, Y.; Funahashi, M.
Jinrui Idengaku Zasshi. Japanese Journal of Human Genetics 33(3): 349-353
1988
ISSN/ISBN: 0021-5074 PMID: 3204688 Document Number: 308654
Lymphocytes from four patients with tuberous sclerosis (TS) and four normal controls were studied for sister chromatid exchanges (SCEs) and chromosome aberrations in gamma-ray irradiated cultures. There was no significant difference between SCE frequencies of TS lymphocytes and those of control lymphocytes at all doses examined (1, 2, and 4 Gy). However, chromosome aberrations in TS lymphocytes were significantly higher than those in the normal controls at the highest dose (4 Gy) (p < 0.05).