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Correlation of the sister chromatid exchange level with chromosome aberrations induced by chemical mutagens in vivo

Shcheglova, E.G.; Chebotarev, A.N.

Biulleten' Eksperimental'noi Biologii i Meditsiny 96(12): 67-69

1983

ISSN/ISBN: 0365-9615
PMID: 6419793
Document Number: 214913
The data on the dose dependencies of the induction of sister chromatid exchanges (SCE) and chromosomal aberrations during exposure of mouse bone marrow cells in vivo to 5 alkylating substances are provided. The efficacy of SCE induction was found to be higher than that of chromosomal aberrations. It was established that SCE induced by chemical mutagens in vivo and in vitro are more sensitive and stable tests than chromosomal aberrations.

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