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Analysis of cell kinetics, chromosome aberration frequency and sister chromatid exchanges in lymphocyte "in vitro" cultures of patients irradiated by 131I. Preliminary note

Ardito, G.; Lamberti, L.; Cottino, F.; Piccotti, F.

Bollettino della Societa Italiana di Biologia Sperimentale 59(2): 135-141

1983

ISSN/ISBN: 0037-8771
PMID: 6860485
Document Number: 204794
In the present note we analyse the possible effect of 131I administration on lymphocyte cultures or patients previously subjected to thyroidectomy because of carcinoma. Three parameters were taken into consideration: cell kinetics, SCE frequency and chromosome aberrations frequency before and after treatment. It is possible to point out only an increase of chromosome aberrations. Our data stress the importance of considering several variables at the same time when we are faced with the problem of evaluating possible DNA damage.

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