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Nucleotide sequence of the transforming region of human cytomegalovirus

Kouzarides, T.; Bankier, A.T.; Barrell, B.G.

Molecular Biology and Medicine 1(1): 47-58

1983

ISSN/ISBN: 0735-1313
PMID: 6092826
Document Number: 218838
We report the nucleotide sequence of a BamHI-HindIII fragment of human cytomegalovirus containing the region (XbaI-HindIII) capable of transforming NIH3T3 cells. The single EcoRI site, shown to abolish transforming activity if cleaved, is present within an 8 base-pair inverted complementary repeat. Close to this sequence there is a small, potentially spliced, open reading frame possessing some of the signals involved in eukaryotic gene expression. Possible mechanisms of transformation, involving the inverted repeat sequence, are discussed.

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